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Monitor Carefully (1)phenobarbital will minimize the level or effect of losartan by influencing hepatic/intestinal enzyme CYP3A4 metabolism.Monitor Carefully (1)phenobarbital will lower the level or effect of mifepristone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers have not been examined, coadminis